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There is something wrong with + (noun)
You are informing someone that there is something not right or out of the ordinary.
Here are some examples:
"There is something wrong with my laptop."
"There is something wrong with my car."
"There is something wrong with my cell phone."
"There is something wrong with my head."
"There is something wrong with your answering machine."
"There is something wrong with your way of thinking."
"There is something wrong with your attitude."
"There is something wrong with your dog."
"There is something wrong with our relationship."
"There is something wrong with our alarm clock."
How come + (subject + verb)
When using 'how come' you are asking why a particular thing has or had to take place.
Here are some examples:
"How come parents worry so much?"
"How come people carpool to work?"
"How come you are so upset?"
"How come he will not call you?"
"How come you stayed out so late?"
"How come you cannot make a decision?"
"How come you always question me?"
"How come we never agree?"
"How come your dog digs in the yard?"
"How come she will not come over?"
What if + (subject + verb)
Here you are asking a question about 'in the event of' or 'in the event that.' Usually you are looking for an answer at the time of the question that is being asked.
Here are some examples:
"What if I miss the bus?"
"What if I were late to dinner?"
"What if I called her tomorrow?"
"What if I don't understand?"
"What if someone sees me?"
"What if no one is home?"
"What if they decide to stay?"
"What if it rains while we are camping?"
"What if I do not finish on time?"
"What if we introduce ourselves first?"